PRA rcd4 RESULTS

[Gillian Kennedy-Sloane]

As an interim measure until the official register provided by the Kennel Club is fully up and running, the SEISC has decided to offer an opportunity for owners to post their recent PRA rcd4 DNA test results.
This will be on our PRA rcd4 page.
This is available to all owners worldwide not just SEISC members and will be in a similar format to that already used by the Kennel Club.

For further details please see the Club website www.seisc.co.uk.

 

Listing will be available sometime today - slight kink in my "html"  !!

[colette tuite]

Yes he was!

[colette tuite]

I  should have said that the Lusca;s mentioned previously were nice looking animals.Steve Robinsons Lusca Perry and Lusca Max were eye catching workers being beautifully trained to have excellent quartering patterns delivered with both style and certainly speed.

[Živa Zupančič]

Can I just ask you how long were you waiting for the results? I've sent samples to AHT previous Saturday (not just for PRA rcd 4, but anyway).
Thank you, Živa
Keep your fingers crossed for us :)

[Živa Zupančič]

Thank you for your answers. I'll write them right away. I hope everything is ok.

[Lena]

I just want to point out one thing that certainly is obvious to most people but apparently not to all:
With any autosomal recessive inheritance, when knowing the status of one dog you can never draw any conslusions about the status of brothers and sisters. Under certain circumstances you can do this from results for children and/or parents, but for example an affected dog can still have clear siblings.

[Chantal McIlveen-Wright]

Mutation is a well known process in genetic, so if mutants are possible, nothing but a DNA test can confirm if the dog is clear, carrier or affected. Inferring from parents or sibling can indeed give a very high level of probability but still, it remains an open door to possible wrong results.... 

[Henriette van der Zwan]

Dear Lena,

Yes this is always a difficult thing for a lot of people to understand. Each human and animal has two copies of each gene. One of each copy is inherited from each parent. Every pup can only inherit one copy of the gene from each parent and it is a totally random event. There is nothing you can do to "make" the dog pass on the clear copy (I've been asked this a couple of times :-) )

If the dog inherit two normal copies, it has to be clear. If it inherits one normal and one mutant copy, it is a carrier and two mutant copies, affected. If one parent is a carrier and one clear, each pup in the litter has a 50/50% chance to be clear or a carrier. There is a common misunderstanding that it is half of the litter clear, half carrier but this is on average (similar to having females/males...some litters has 50% males 50% females, others more males or more females, but on average if a parent pair could have 1000 pups they would have 50% females and 50% males) but this is wrong. If two carriers are mated, each pup can inherit either a normal or a mutant copy of the gene from each parent. Therefore each pup has a 25% to be clear, 25% to be affected and 50% to be a carrier. A clear x affected mating can only produce carriers. If both parents aren't tested there is no way of knowing that all littermates are clear/carrier. If one parent is clear you can rule out affected pups, though.

[silvia]

well, of course an affected dog can have clear siblings, if is coming from carrier+carrier for instance.. but that should be quite obvious no? an affected dog can not have clear puppies, that's for sure.. at most he can have carriers in his progenies..

[Marion Didicher]

Today we received the test results of our 4 breeding dogs:

Red Tails Hazel the Red Love - CLEAR

Red Suits You Are Red Love - CARRIER

Be my Red Love of the Autumm Sun - CARRIER

The Red Love XL Fire of Mimosa - CARRIER.

We are glad that no dog is affected!

[Živa Zupančič]

Today I received an email, that everything is ok and that the testing is in the process. Now we are waiting for the results. :) I will let you know about them.

[Ann Millington]

Can I ask, please, how many of the dogs that have been DNA tested for LOPRA - whichever mutation - are actually blind?

Is the testing being done just to clear breeding or is it because owners have recently become more aware of failing sight?

[Melinda Auld]

I  would be interested in knowing this too.  It seems - from the numbers of carriers coming through - that either this mutation is a fairly new development in the breed, or perhaps there is something more to it.  Otherwise, surely with the large percentage of carriers, there should be many more affected dogs in the breed?  Also, those who are affected are not necessarily blind (nor do some ever seem to go blind from LOPRA).  So could this mean there is also a masking gene at work here?  Or some sort of genetic "switch" which "activates" the gene into causing blindness?

 

All very interesting.